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NCT00785564 Clinical Trial

Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

Sick Sinus Syndrome Clinical Trial

Official title:
Imaging Cardiac Electrical Remodeling With ECGI

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00785564
Other study ID # 07-0995
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 2007
Est. completion date September 2011

Study information
Verified date January 2019
Source Washington University School of Medicine
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Recruitment information / eligibility
Status Completed
Enrollment 13
Est. completion date September 2011
Est. primary completion date September 2011
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion Criteria:

- Persistent atrial fibrillation that is not suppressed by medications.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Washington University School of Medicine Saint Louis Missouri

Sponsors (1)
Lead Sponsor Collaborator
Washington University School of Medicine

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary ECGI Image 1 month after RV pacing
See also
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Recruiting NCT01477138 - RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome N/A
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Completed NCT00161538 - Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Phase 4