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Osmolality of Oral Supplements and Ileostomy Output

Short Bowel Syndrome Clinical Trial

Official title:
Does Osmolality of Oral Supplements Affect Stoma Output and Natriuresis in Patients With an Ileostomy?

Clinical Trial Summary

This double-blinded, active comparator, cross-over intervention study tested the impact of two different oral supplements on ileostomy output volume and urinary sodium excretion and intestinal aquaporin expression in eight compensated patients with an ileostomy and not on home parenteral Nutrition or fluid support.

Clinical Trial Description

Patients with an ileostomy may experience fluid and electrolyte imbalances sedondary to an unregulated intestinal loss of water and electrolytes. The osmolality of oral supplements may affect these losses. In a double-blinded, active comparator, cross-over intervention study, the investigators test the effects of substituting 800 ml of the usual fluid intake with an intake of either an isoosmolar (300 mOsm/kg) or hyperosmolar (700 mOsm/kg) supplement during 48 hours, following baseline data collection before both intervention periods. Outcome measures were stoma output volume, 24-hour urine and urinary sodium excretion, and intestinal aquaporin 3 and 8 expressions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03348709
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date June 1, 2017
Completion date November 1, 2018
View Details
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