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Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients

Shock, Septic Clinical Trial

Official title:
Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients

Clinical Trial Summary

After initial hemodynamic stabilization, 36 septic shock patients with heart rate > of 90 bpm and requiring norepinephrine to maintain mean arterial pressure (MAP) more than 65 mmHg will be randomised into two groups, esmolol group and control group. Patients allocated to esmolol group will receive a continuous esmolol infusion to maintain a lowering of heart rate of 10%. Norepinephrine will be titrated to achieve a MAP more than 65 mmHg. To investigate myocardial performance, the investigators will assess Tissue Doppler imaging by echocardiography and hemodynamic measures. Data will be obtained at baseline ,after esmolol infusion once achieved the predefined heart rate threshold and 72hours after esmolol infusion.

Clinical Trial Description

primary outcome were determined according to our previous study of tissue doppler. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02842983
Study type Interventional
Source Peking Union Medical College Hospital
Contact Yong-tai Liu, MD
Phone +861069155068
Email ataiever@163.com
Status Recruiting
Phase Phase 2/Phase 3
Start date December 2014
Completion date December 2016
View Details
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