Severe Falciparum Malaria Clinical Trial
Official title:
Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
acidosis, acute renal failure and acute pulmonary oedema are common, and frequently fatal,
manifestations of severe P. falciparum malaria. The course of all three might be ameliorated
by optimising a patient's intravenous fluid therapy. The fluid treatment of severe malaria
is presently empirical, by defining cardiovascular responses to volume replacement we would
provide a physiological basis for resuscitation strategies.
We will use pulse contour cardiac output monitoring (PiCCOTM) to guide the fluid
resuscitation of patients admitted to intensive care with severe malaria. With data
collected during the patients' admission we hope to:
1. Assess the degree of hypovolaemia in adults with severe malaria and its contribution to
microcirculatory dysfunction and acidosis.
2. To assess the relationships between volume status, haemodynamic parameters and the
renal and pulmonary manifestations of severe malaria.
3. To assess the utility of central venous pressure measurement as a guide for fluid
administration in patients with severe malaria
4. To investigate the prognostic and clinical utility of central venous oxygen saturation
in severe malaria
In this way we hope to develop a greater understanding of the pathophysiology of
haemodynamic derangement in severe malaria. By comparing the PiCCO derived data with simpler
clinical parameters, we hope to determine potential fluid resuscitation strategies -
relevant for a resource poor setting - whose efficacy could be confirmed in future trials.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Suspended |
NCT00616304 -
Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria
|
Phase 2 |