Clinical Trials Logo

Clinical Trial Summary

Severe infections (sepsis) are a frequent cause of admission to the intensive care unit. Sepsis represent a significant risk for the health of patients in the short and medium term. Sepsis are notably linked to a change in the function of immune cells. In some patients, a state of pseudo-dormancy of monocyte and macrophage immune cells, called myeloid cell immunosuppression, is observed. This situation, which leads to a worsening of the infection, must be avoided because it represents a danger for the patient, even during antibiotic therapy. At present, these events are still very poorly understood. Research is needed to understand how the immunosuppression of myeloid cells occurs in order to adapt existing treatments or to find new ones. Laboratory work on animal models of sepsis has shown that this state of myeloid cell immunosuppression is closely linked to a modification of energy production by myeloid cells (monocytes and macrophages). The function of the mitochondria ("energy factory" of the cells) in these cells is impaired. Thus, restoring mitochondrial function in myeloid cells could be a therapeutic solution against the immunosuppression of myeloid cells during severe sepsis. The aim of this study is to verify whether alterations in mitochondrial function in myeloid cells occur in both patients with and without bacterial infection.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05040503
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact Jean-Pierre QUENOT
Phone 03 80 29 36 85
Email jean-pierre.quenot@chu-dijon.fr
Status Recruiting
Phase N/A
Start date August 25, 2021
Completion date September 2024

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT04764058 - Efficacy and Safety of Colistin Based Antibiotic Therapy Phase 1/Phase 2
Completed NCT03088865 - Evaluation of an Internal Hospital Practice: The Effect of Altered Test Tubes Sampling Order on Blood Culture Contamination Rates N/A
Completed NCT00046072 - A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis Phase 2
Completed NCT01520597 - National Study on Listeriosis and Listeria
Recruiting NCT03929159 - Correlating MicroRNA Changes With Sepsis Outcomes
Completed NCT03943719 - Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia
Completed NCT00901940 - Understanding the Immune Response to Meningitis Vaccines Phase 3
Not yet recruiting NCT03583762 - Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique N/A
Completed NCT02988414 - Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay
Completed NCT02102087 - Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device N/A
Recruiting NCT05045963 - Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
Terminated NCT02093494 - Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters N/A
Active, not recruiting NCT02069028 - Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis N/A
Recruiting NCT00258869 - Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests N/A
Completed NCT05358912 - Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock Phase 4
Recruiting NCT05893420 - A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning N/A
Completed NCT00146432 - Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1) Phase 2/Phase 3
No longer available NCT04636554 - Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia or Bacteremia/Septicemia