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NCT03943719 Clinical Trial

Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia

Septicemia Clinical Trial

— SEPSIS2016  

Official title:
The Impact of a Rapid Molecular Identification Test on Positive Blood Cultures From Critically Ill With Bacteremia: a Pre-post Intervention Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03943719
Other study ID # SEPSIS2016
Secondary ID 2016/19SEP/401
Status Completed
Phase
First received
Last updated
Start date March 1, 2017
Est. completion date August 31, 2018

Study information
Verified date May 2019
Source Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique reserved for specific patient populations. In our study, we specifically evaluated molecular testing in a critical care setting and measured its impact on the therapeutic management of critically ill with positive blood cultures. Through the analysis of 110 positive blood culture episodes included in both pre- and post intervention period, we measured a drastic 14h-reduction of the time to administration of the optimal antimicrobial treatment with the use of the molecular approach.

Recruitment information / eligibility
Status Completed
Enrollment 139
Est. completion date August 31, 2018
Est. primary completion date December 31, 2017
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- adult intensive care unit patients with positive blood cultures

Exclusion Criteria:

- palliative care patients

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• FilmArray blood culture identification panel
FilmArray blood culture identification panel is performed 24 hours on 24hours and 7 days a week on positive blood cultures to accelerate pathogens detection

Locations
Country Name City State
Belgium Cliniques universitaires St-Luc Brussels

Sponsors (2)
Lead Sponsor Collaborator
Cliniques universitaires Saint-Luc- Université Catholique de Louvain BioMérieux

Country where clinical trial is conducted

Belgium, 

Outcome
Type Measure Description Time frame Safety issue
Primary Turn Around Time to optimal treatment of septicemia Time in minutes From positivity detection of positive blood culture to administration of optimal treatment (up to 48 hours)
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