Septicemia Clinical Trial
Official title:
Evaluation of an Internal Hospital Practice: The Effect of Altered Sampling Protocol on Blood Culture Contamination Rates: An Open, Randomized, Prospective Study
Verified date | February 2020 |
Source | Hadassah Medical Organization |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Implementation of the initial specimen diversion technique, in which the first milliliter of the venipuncture sample is not injected into the culture bottle, led to a significant reduction in blood culture contamination rates. This technique is based on the assumption that the skin plug aspirated during venipuncture is a major source of contaminating bacteria. One such diversion method is aspirating the first blood volume into a blood collection tube. It has, however, been suggested that regular blood collection tubes carry contaminants from the tube's stopper into the blood cultures drawn afterwards, thereby increasing contamination rates. The aim of this trial is to examine the effect of aspirating the first blood volume into a regular blood collection tube on blood culture contamination rate.
Status | Completed |
Enrollment | 756 |
Est. completion date | September 6, 2018 |
Est. primary completion date | September 6, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adults evaluated in the emergency room or as inpatients for suspected sepsis or having sepsis and from whom the treating physician plans to take, in the same venous puncture, blood cultures and additional blood tests (blood count and/or blood chemistry). Exclusion Criteria: - None |
Country | Name | City | State |
---|---|---|---|
Israel | Hadassah Medical Center | Jerusalem |
Lead Sponsor | Collaborator |
---|---|
Hadassah Medical Organization |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood culture contamination rate | A blood culture contamination is defined as growth in a single set of coagulase-negative Staphylococcus, Micrococcus, Viridans group Streptococcus, Propionibacterium acne, Corynebacterium sp (diphtheroids) or Bacillus sp. | 7 days |
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT04764058 -
Efficacy and Safety of Colistin Based Antibiotic Therapy
|
Phase 1/Phase 2 | |
Completed |
NCT00046072 -
A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis
|
Phase 2 | |
Completed |
NCT01520597 -
National Study on Listeriosis and Listeria
|
||
Recruiting |
NCT03929159 -
Correlating MicroRNA Changes With Sepsis Outcomes
|
||
Completed |
NCT03943719 -
Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia
|
||
Completed |
NCT00901940 -
Understanding the Immune Response to Meningitis Vaccines
|
Phase 3 | |
Not yet recruiting |
NCT03583762 -
Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique
|
N/A | |
Completed |
NCT02988414 -
Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay
|
||
Completed |
NCT02102087 -
Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device
|
N/A | |
Recruiting |
NCT05045963 -
Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
|
||
Terminated |
NCT02093494 -
Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters
|
N/A | |
Active, not recruiting |
NCT02069028 -
Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis
|
N/A | |
Recruiting |
NCT00258869 -
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
|
N/A | |
Completed |
NCT05358912 -
Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock
|
Phase 4 | |
Recruiting |
NCT05893420 -
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
|
N/A | |
Recruiting |
NCT05040503 -
Monitoring Mitophagy In Myeloid Cells Upon Intensive Care
|
N/A | |
No longer available |
NCT04636554 -
Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia or Bacteremia/Septicemia
|
||
Completed |
NCT00146432 -
Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
|
Phase 2/Phase 3 |