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Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients — MYTHICCS  

Septic Shock Clinical Trial

Official title:
Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients

Clinical Trial Summary

Compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C and evaluate intra-individual variation of hemodynamic parameters between T0 and T1.

Clinical Trial Description

This is a transversal study allowing to compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C. Design: • A monocentric, open-label, transversal study Sample size : 30 patients Assessement: Between 6 hours and 24 hours after admission, the patient will be included after collection of the non opposition. There will be two evaluation times: T0 before the start of vitamin C's perfusion, and T1: 1 hour after the end. No interim analysis is planned. Analysis will be performed at the end of the study after data review and freezing of data base. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04778605
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact Hafid AIT-OUFELLA, Professor
Phone 0149282315
Email hafid.aitoufella@aphp.fr
Status Recruiting
Phase
Start date January 26, 2021
Completion date July 2021
View Details
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