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Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients — ClMLsepsis  

Septic Shock Clinical Trial

Official title:
Muscle Lactate and Lactate to Pyruvate Ratio Clearance as Useful Biomarkers for the Prediction of Mortality in Septic Shock Patients

Clinical Trial Summary

We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.

Clinical Trial Description

Microcirculatory alterations are frequently observed in patients with sepsis. In vivo microdialysis (MD) is a bedside technique that can monitor tissue metabolic changes. We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis. Interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline and every 6 hours for 3 days by using muscle microdialysis. Clearances of muscle lactate, and L/P ratio were defined as the percentage change in muscle lactate level or L/P ratio compared to baseline (H0) values. A positive value of clearance means a decrease in the rate of the parameter under study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03700346
Study type Interventional
Source Military Hospital of Tunis
Contact
Status Completed
Phase N/A
Start date January 1, 2018
Completion date December 31, 2018
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