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Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

Septic Shock Clinical Trial

Official title:
Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock: A Randomised Controlled Study

Clinical Trial Summary

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients with septic shock.

Clinical Trial Description

The study was designed as a prospective, double-blind, controlled, clinical trial and performed in a multidisciplinary intensive care unit. After achieving normovolemia and a mean arterial pressure of at least 65 mmHg, 20 septic shock patients were randomized to receive either levosimendan 0.2 μg/kg/min, or dobutamine 5 μg/kg/min. Interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained by using muscle microdialysis. All measurements, including data from right heart catheterization were obtained at baseline and every 6 hours for the following 72 hours after randomization. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02963454
Study type Interventional
Source Military Hospital of Tunis
Contact zied hajjej
Phone 20358907
Email hajjej_zied@hotmail.com
Status Recruiting
Phase N/A
Start date January 2011
Completion date February 2018
View Details
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