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Methylene Blue in Severe Sepsis and Septic Shock

Septic Shock Clinical Trial

Official title:
Infusion of Methylene Blue in Severe Sepsis and Septic Shock: Randomized, Single Blinded

Clinical Trial Summary

This study is to see whether the intravenous administration of methylene blue improves the outcome in severe sepsis and septic shock.

Clinical Trial Description

The mortality of septic shock is still high ranging from 30 to 50%. Vasopressor is the main part in managing septic shock, but the choice of vasopressor is still under-investigated, and area of uncertainty.

The response to vasopressor is sometimes unsatisfactory, and in that case, the outcome of the patients is poor.

Recently, small size clinical trial has investigated the effect of methylene blue (MB), and showed promising results. However, large sized phase III trial has not been performed yet.

Large sized phase III clinical trial is needed to establish the effect of MB in septic shock. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01797978
Study type Interventional
Source Seoul National University Hospital
Contact Kyuseok Kim, MD
Phone +82-31-787-7572
Email dremkks@snubh.org
Status Recruiting
Phase Phase 3
Start date February 2013
Completion date March 2017
View Details
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