Phenylephrine in Septic Shock

Status Completed

Clinical Trial Summary

The present study was conducted as a prospective, randomized, controlled study to compare:

- the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock

- to test the hypothesis that norepinephrine may likewise better preserve hepatosplanchnic perfusion versus phenylephrine in patients suffering from septic shock

Clinical Trial Description

Thirty two septic shock patients requiring vasopressor support to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation will be enrolled in the study. Patients will be randomly allocated to be treated with either a) titrated phenylephrine, b) titrated norepinephrine (control; each n = 16), to achieve a mean arterial pressure (MAP) between 65 and 75 mmHg, if necessary. Data from right heart catheterization, thermo-dye dilution catheter, gastric tonometry as well as data from organ function, will be obtained at baseline and after 12 hours. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00639015
Study type	Interventional
Source	University of Roma La Sapienza
Contact
Status	Completed
Phase	Phase 2
Start date	November 2007
Completion date	June 2008

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See also
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