Short Term Results of Pediatric Septic Hip Arthritis Management in Assiut University Hospitals

Septic Arthritis Clinical Trial

Official title:

Short Term Results of Pediatric Septic Hip Arthritis Management in Assiut University Hospitals

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05780697
• Other study ID #: Pediatric Septic Hip arthritis
• Status: Not yet recruiting
• Phase: N/A
• Start date: March 2023
• Est. completion date: March 2025

Study information

• Verified date: March 2023
• Source: Assiut University
• Contact: Beshoy Elkes Abram, Resident Dr
• Phone: 01284144493
• Email: Beshoelghalban_2010[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Detect short term results of pediatric septic hip arthritis and its risk factors

Description:

Septic arthritis of the hip is a true orthopedic emergency(1). In developed countries, the incidence of acute bacterial septic arthritis is estimated to be 4 to 10 per 100,000 children (2).It is caused by many microorganisms. Staph aureus is most common in children over 2 years of age . Staph aureus is gram-positive cocci in clusters and most common in nosocomial infections of neonates(3-4).Group B streptococcus is most common in neonates with community-acquired infection and exposed during transvaginal delivery(5).Neisseria gonorrhoeae is gram-negative diplococci and most common in adolescents.when the causative Organism is Neisseria gonorrhoeae ,patients usually have a preceding migratory polyarthralgia,multiple joint involvement and small red papules(6-7).Group A beta-hemolytic streptococcus is most common organism following varicella infection.HACEK organisms (Haeophilus,Actinobacillus,Cardiobacterium,Eikenella,and Kingella fastidious) are less common causative organisms(8-9).Early diagnosis and accurate treatment is key in avoiding complications such as joint destruction,joint dislocation , ankylosis, growth arrest or spread of infection leading to osteomyelitis , pelvic abscess or nerve lesions.. Treatment is started without delay after synovial fluid and blood samples have been obtained. The classical presentation of septic hip arthritis in children is a combination of a painful hip joint with limited range of motion, fever, malaise and inability to bear weight on the affected limb. Misdiagnosis or inappropriate treatment of acute septic arthritis of the hip in children can result in devastating damage of the joint and possible lifelong disability. Open arthrotomy , drainage and thorough irrigation of the joint is considered the standard treatment for septic arthritis of the hip.Empiric antibiotic treatment primarily targets S. aureus and takes into account its resistance to antibiotics(10-11). So,we want to detect short term results of pediatric septic hip arthritis at Assiut University Hospitals

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: March 2025
• Est. primary completion date: March 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 1 Day to 14 Years

Eligibility

Inclusion Criteria:

• Children younger than 14 years old presented with septic hip arthritis only or by bilateral septic hip arthritis in Assiut University Hospitals

Exclusion Criteria:

• 1-patients with Tuberculous arthritis 2-patients whose parents refuse to participate in the study

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Infectious
• Septic Arthritis

Intervention

Procedure:
• Surgery of Drainage of septic hip arthritis
Surgery for septic hip arthritis by anterior or lateral approach and inspection of femoral head

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (2)

Fabry G, Meire E. Septic arthritis of the hip in children: poor results after late and inadequate treatment. J Pediatr Orthop. 1983 Sep;3(4):461-6. doi: 10.1097/01241398-198309000-00008. — View Citation

Ilharreborde B. Sequelae of pediatric osteoarticular infection. Orthop Traumatol Surg Res. 2015 Feb;101(1 Suppl):S129-37. doi: 10.1016/j.otsr.2014.07.029. Epub 2014 Dec 29. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Modified Moon's criteria for outcome assessment of hip function		Baseline
Secondary	Detection of Complications	Complications such as limb-lenght discrepancy , Avascular necrosis of the femoral head and hip destruction will be documented	Baseline