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Clinical Trial Summary

PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments. Treatable traits, therapeutic targets identified by phenotypes or endotypes (defined by biological mechanism or by treatment response) through validated biomarkers (measurable characteristic reflecting normal or pathogenic processes, or treatment responses), may include multi-omics, cellular, immune, metabolic, endocrine features, or intelligent algorithms. PALETTE Bayesian adaptive design enables parallel investigations of multiple interventions for sepsis, and quick inclusion of pandemic pathogens. PALETTE's new conceptual model will respond to the challenges of standard approaches, i.e. series of sepsis trials, each investigating one or two interventions, expensive, time consuming, and inappropriate in pandemic context.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06381661
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Djillali Annane, Pr
Phone +33147107787
Email djillali.annane@aphp.fr
Status Not yet recruiting
Phase Phase 3
Start date April 1, 2026
Completion date April 1, 2032

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