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NCT06289179 Clinical Trial

Thyroid and Cortisol Hormone Response to Sepsis

Sepsis Clinical Trial

Official title:
Thyroid and Cortisol Hormone Response in Patients With Sepsis Who Attended To Assiut University Hospitals (ICU)

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06289179
Other study ID # Thyroid and cortisol in sepsis
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date March 1, 2024
Est. completion date October 25, 2026

Study information
Verified date February 2024
Source Assiut University
Contact Sara Mahmoud khalf allah Mohamed
Phone 01099929480
Email saramm302@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Thyroid and cortisol hormone response to sepsis

Description:

Sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 114
Est. completion date October 25, 2026
Est. primary completion date February 20, 2026
Accepts healthy volunteers
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria: - The study will include Adults (=18 years), both genders - septic patients admitted to critical care unit Exclusion Criteria: - thyroid disease - hypopituitarism - Addison disease - Cushing syndrome)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

References & Publications (1)

Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB. Thyroid abnormalities in term infants with fungal sepsis. Rev Assoc Med Bras (1992). 2016 Sep;62(6):561-567. doi: 10.1590/1806-9282.62.06.561. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Pattern of cortisol level and thyroid function response to sepsis in ICU Affect of sepsis on hormones at ICU:compare the change of endocrinal hormones ( TSH (mIU/L) .T3(ng/dL) .T4 ( mcg/dL) adrenocorticotropic hormone "ACTH" (pg/mL) , cortisol (µg/dL)) at time of admission, course ICU ,3rd day after discharge From time of admission to ICU up to 3rd day after discharge
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