Heparin Binding Protein as a Prognostic Biomarker of Sepsis Severity

Sepsis Clinical Trial

Official title:

Heparin Binding Protein as a Reliable Prognostic Biomarker for Severity of Sepsis in the Intensive Care Unit

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05610020
• Other study ID #: FMASU M D 159/ 2021
• Status: Completed
• Start date: October 1, 2021
• Est. completion date: October 1, 2022

Study information

• Verified date: November 2022
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

the aim of the study is to correlate between the severity of sepsis and serum heparin binding protein in the patients admitted to ICU with sepsis., and detect its value as a prognostic biomarker in sepsis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 55
• Est. completion date: October 1, 2022
• Est. primary completion date: August 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• adult whose age between 20 to70 years old

• patients suffered from sepsis or septic shock (under the third international consensus definition of sepsis and septic shock)

Exclusion Criteria:

• Any pregnancy female

• Any patient who is Neutropenic secondary to malignancy

• Patients who is taking immunosuppressive therapy

• Patients who is suffering fromHematological malignancy

Related Conditions & MeSH terms

• Sepsis
• Toxemia

Locations

Country	Name	City	State
Egypt	Omar Hamdy	Minya

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluate the level of Heparin binding protein in relation to patient clinical improvement measured by SOFA Score	Correlates the change of the level of Heparin binding protein in ng/ml to the clinical improvement of the patients which is measured by SOFA score	72 hours after meeting sepsis ceriteria
Secondary	Heparin binding protein and mortality	Correlates the change of the level of Heparin binding protein in ng/ml And how can it is used to predict mortality	28 days after meeting sepsis ceriteria