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Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic.

Sepsis Clinical Trial

Official title:
Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic: A Randomized Control Trial.

Clinical Trial Summary

Sepsis is an inflammation response produced by the host's immune system, which is agrravated by oxidative stress. One of the adjuvant therapy according to Surviving Sepsis Campaign Guideline is albumin, which has anti-inflammatory and anti-oxidant effects. However, human albumin is quite expensive, and other forms with similar potency and less costs are needed, one of which is Channa striata extract. Therefore, this study is conducted to compare albumin and human albumin, specifically their anti- inflammatory and anti-oxidant properties by assessing the eNOS marker, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patient with sepsis.

Clinical Trial Description

In summary, this study showed that Channa striata extract has a better outcome in stabilizing eNOS level in patient with sepsis than human albumin 20%, and it has a potential benefit in stabilizing NLR values. However, further studies with a larger sample and a more advanced phase of sepsis are needed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05596942
Study type Interventional
Source Universitas Sebelas Maret
Contact
Status Completed
Phase Phase 3
Start date July 1, 2021
Completion date September 30, 2021
View Details
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