Sepsis Clinical Trial
Official title:
Capnodynamic Monitoring of Cardiorespiratory Function in Patients Admitted to the Intensive Care Unit With COVID-19 Infection, Sepsis and Following Cardiac Surgery
Capnodynamic monitoring has the potential to offer continuous and non-invasive measurements of heart and lung function in patients requiring ventilation in an intensive care setting. Since mechanical ventilation with full patient synchronization is commonly used in ICU, capnodynamic monitoring can be immediately embedded in clinical care and compared to current methods of monitoring cardiac output, lung volumes and oxygen delivery. This observational study will explore capnodynamic monitoring in mechanically ventilated patients with a range of cardiorespiratory compromise.
This study aims to: 1. compare the estimation of cardiac output (CO) using the capnodynamic method (COEPBF) with contemporary reference methods; 2. compare the estimation of mixed venous oxygen saturation (SmvO2) with invasively obtained blood gas analyses; 3. generate observational data on end-expiratory lung volume (EELV) when ventilator settings, and in particular PEEP, are changed; 4. combine 1-3 to provide a physiological construct of cardiorespiratory function ;
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