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Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock

Sepsis Clinical Trial

Official title:
Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock

Clinical Trial Summary

Due to the high incidence, mortality and short and long term complications of sepsis and septic shock, it is necessary to look for strategies to try to minimize this impact.

Clinical Trial Description

Based on the current literature, we can affirm that the decrease in ascorbic acid levels in patients with sepsis and septic shock is directly proportional to the evolution to multiorgan failure and inversely proportional to survival. After assessing the safety in the administration of ascorbic acid as well as the decrease or almost abolition of its impact at the renal level after the association of thiamine, and the synergy provided by the administration of hydrocortisone, it is decided to implement the "Metabolic Resucitation Protocol" and assess its impact on our septic patients ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04111822
Study type Interventional
Source Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Contact
Status Completed
Phase Phase 3
Start date October 31, 2018
Completion date October 31, 2020
View Details
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