Sepsis Clinical Trial
Official title:
Dissecting How Peripheral Lymphocytes Are Lost During Sepsis
There is an observational, clinical study. We recruit sepsis patients to investigate what drives peripheral lymphocyte loss in sepsis.
There is an observational, clinical study. We recruit patients with diagnosis of new onset
sepsis within 24h, collect and record clinical characteristics：
①Demography data，diagnosis, admission source, infection source, APACHE II,SOFA
scores;②Endotoxin levels and PaO2 measured;③Immune and systemic inflammatory indicators：T,
RR, WBC, ALC, etc.;④Complicated organs dysfunctions: duration and therapy;⑤Incidence of
ICU-acquired infection and prognosis.The blood samples were collected for
apoptosis,necrosis,autophagy,pyroptosis measurements.The aim of this study is to investigate
how peripheal lymphocyte loss relates to outcome and the mechanisms of peripheal lymphocyte
loss in different condition.
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