Sepsis Clinical Trial
Official title:
Investigation of The Prevalence of Sepsis in Adults in Multicenter Intensive Care Unıts in Turkey
The pathophysiology and treatment of sepsis disease are still not fully known. International guides often refer to the studies done in the developed countries and suggest some treatments. The infrastructure of the developing countries is quite different. For this reason, it is not exactly scientific how much these proposals are reflected in patient treatment. In our study, We will try to reveal the treatment of sepsis.
Sepsis is a clinical syndrome that has physiologic, biologic, and biochemical abnormalities
caused by a dysregulated inflammatory response to infection. Sepsis and the inflammatory
response that ensues can lead to multiple organ dysfunction syndrome and death. In the late
1970s, it was estimated that 164,000 cases of sepsis occurred in the United States (US) each
year. Since then, rates of sepsis in the US and elsewhere have dramatically increased as
supported by the following studies, although many of these are derived from academic
institutions. The increased rate of sepsis is thought to be a consequence of advancing age,
immunosuppression, and multidrug-resistant infection. It is also likely to be due to the
increased detection of early sepsis from aggressive sepsis education and awareness campaigns,
although this hypothesis is unproven. Guidelines should focus on pre-hospital assessment and
triage. Indeed, respiratory infections represented the most common cause of sepsis in that
cohort, and postoperative infections were another important part of the problem. Whether
these conditions apply to patients with shock in low-income and middle-income countries
(LMIC) is unknown, but the incidence of community-acquired infections would be higher, with a
greater prevalence of gastroenteritis, septic abortion, and skin and soft tissue infections
as causes of septic shock. The bacteriology of bloodstream infections across LMICs varies
substantially depending on regional and population characteristics. In a meta-analysis of 19
prospective studies on community-acquired bacteraemia in Africa, the most common organisms
isolated were Salmonella spp (predominantly non-typhi), Streptococcus pneumoniae, and
Gram-negative organisms such as Escherichia coli.11 Among cases for which mortality data were
recorded, patients with bloodstream infections had an average mortality of 21.5%. Although
data are lacking, appropriate antibiotic treatment for these infections on the basis of
bacterial resistance patterns will ultimately depend on the ecological pressures resulting
from local antibiotic availability and patterns of use.
We aimed to evaluate the approach to sepsis in Turkey as a multi-centered study.
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