Sepsis Clinical Trial
Official title:
The Application of Infrared Thermal Imaging in the Diagnosis and Prognostication of Septic Illness in Adults
The application of infrared thermal imaging in the diagnosis and prognostication of septic
illness in adults.
During times of severe infection (sepsis), the small blood vessels supplying oxygen and
nutrients to the skin and other organs (called the microcirculation), become abnormal and do
not function as they normally would in health. Monitoring these small blood vessels is
difficult to do clinically and the investigators want to investigate a new way of doing this.
The aim of this study is to validate a novel method of assessing the function of the
microcirculation in healthy volunteers and patients with sepsis, by measuring the skin
temperature profile of the leg and face with a thermal imaging camera. Thermal imaging
cameras measure the heat given off by all objects and represents this as a picture, with
colour used to represent the different temperatures.
Patients will be recruited from the Emergency Department and Intensive Care Units at
University Hospitals of Leicester in to one of two groups based on their illness severity;
uncomplicated sepsis and severe sepsis. Healthy volunteers will be recruited in to a third
group. Recruitment will take place over a 6-month period with follow-up lasting for 12-months
following recruitment. 105 participants will be recruited in total.
Temperature patterns seen on the face and leg will be investigated between the different
groups. Changes in these temperature patterns as patients recover from sepsis (or indeed
become worse), will also be investigated. Information from the thermal images will be
correlated to routinely measured markers of infection, including clinical measurements (blood
pressure, pulse, etc) and routine blood investigations.
n/a
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