Sepsis Clinical Trial
Official title:
Plasticity and Regeneration of Renal Epithelial Cells
The incidence of acute kidney injury (AKI) among all hospitalized patients is approximately 7%. Among these patients, sepsis and septic shock remain the most important cause of acute renal failure (ARF) and account for more than 50% of cases of AKI. The goal of this project is to uncover key factors that lead to renal function recovery. This study is planned to survey novel biomarkers that reflect tissue pathology or regeneration. During the hospitalization, blood and urine sample will be collected for NGAL and inflammatory marker analysis in the patients with bacteremia, while the rest sample will be collected for further novel biomarker survey. This study is to early predict the renal function impairment and identify the possible molecule that involved in renal function recovery.
Status | Not yet recruiting |
Enrollment | 400 |
Est. completion date | December 2019 |
Est. primary completion date | December 2019 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion criteria: 1. Newly diagnosed bacteremia with sepsis patients 2. Age more than 20 years old 3. Sign the Permit Exclusion Criteria 1. Predicted not survival longer than 72 hours 2. Pregnant woman |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from Baseline NGAL and KIM-1 at 48-96 hours | Early kidney injury marker using ELISA | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No |
Secondary | Clinical inflammatory markers, including white cell count and CRP | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No | |
Secondary | BUN/Creatinine | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No | |
Secondary | SOFA and qSOFA score | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No | |
Secondary | Novel proteomics markers (Confidential) | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No | |
Secondary | Novel SNP markers (Confidential) | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No | |
Secondary | Novel RNA markers (Confidential) | Two time point: diagnosed day 1 and 48-96 hours after diagnosed day | No |
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