Sepsis Clinical Trial
Official title:
Early Biomarkers of Sepsis Identification in the Emergency Department
Monocentric prospective study on consecutive patients attending the emergency department and suspected to have sepsis. Blood sampling for the measurement of a panel of biomarkers of interest in sepsis.
The management of patients admitted to the emergency department (ED) requires investigative
biological parameters that help clinicians to make the right diagnosis.
Sepsis concerns patients with infection associated with a systemic inflammatory response.
While this inflammatory profile is observed in many clinical situations in the ED, the
challenge is to characterize in these patients suspected of sepsis those who have a real
infection.
Currently, no individual biomarker of sepsis is sufficiently discriminant. The objective of
this study is to measure in patients suspected of sepsis in the emergency department, a
combination of biomarkers (covering several distinct pathophysiological pathways) that could
provide high specificity and sensitivity for the diagnostic and prognostic. The originality
of this study is that compared with patients admitted to intensive care units, patients
investigated for suspected sepsis in the ED are seen earlier in their medical history and
usually before any therapeutic intervention (intravenous fluids, antibiotics, catecholamines)
interfering with several biomarkers of interest.
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|---|---|---|---|
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