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Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy

Sepsis Clinical Trial

Official title:
Elimination of Antibiotics During Combined Continuous Renal Replacement Therapy and Cytosorb Adsorptive Therapy in Patients With Sepsis and Acute Kidney Injury

Clinical Trial Summary

Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate

- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

Clinical Trial Description

Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02611271
Study type Observational
Source Heinrich-Heine University, Duesseldorf
Contact Detlef Kindgen-Milles, Prof.
Phone +49 211 81
Email Kindgen-Milles@med.uni-duesseldorf.de
Status Recruiting
Phase
Start date December 1, 2017
Completion date December 31, 2020
View Details
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