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Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis

Sepsis Clinical Trial

Official title:
Plasma Midkine Associated Organ Dysfunction and Vascular Injury in Sepsis

Clinical Trial Summary

Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ function, and also with plasma ACE and angiotensin II.

Clinical Trial Description

This study showed that Ang II induced endothelial injury in sepsis patients. Midkine has been shown to regulate the renin-angiotensin system and acts in the upstream signaling pathway of angiotensin (ANG) II. The investigators want to access the relationship between midkine level and ACE-Ang II induced endothelial injury in sepsis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02605681
Study type Observational [Patient Registry]
Source Southeast University, China
Contact
Status Completed
Phase
Start date November 1, 2016
Completion date June 15, 2018
View Details
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