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Balanced Salt Solution VS. Normal Saline Solution in Septic Shock

Sepsis Clinical Trial

Official title:
Balanced Salt Solution Versus Normal Saline Solution During Initial Resuscitation in Severe Sepsis or Septic Shock Children: A Randomized Controlled Trial

Clinical Trial Summary

The Purpose of this study is to determine the impact of balanced salt solution versus chloride rich solution on clinical outcomes in paediatric severe sepsis or septic shock

Clinical Trial Description

The surviving sepsis campaign guideline recommended the isotonic crystalloids as the first choice of initial fluid resuscitation. The isotonic crystalloids are including chloride-rich solution (eg.NSS) and balanced salt solution. Retrospective study showed normal saline can induced hyperchloremic metabolic acidosis and acute kidney injury. However, no randomized controlled trial compare efficacy between the balanced salt solution and chloride rich solution. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02336620
Study type Interventional
Source Ramathibodi Hospital
Contact
Status Completed
Phase Phase 3
Start date December 2014
Completion date January 30, 2017
View Details
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