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Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

Sepsis Clinical Trial

Official title:
Research of Little Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

Clinical Trial Summary

The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.

Clinical Trial Description

Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02266589
Study type Interventional
Source Nanjing PLA General Hospital
Contact
Status Completed
Phase Phase 3
Start date November 2011
Completion date October 2013
View Details
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