Sepsis Clinical Trial
Official title:
Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast (NE) Thailand
This is an observational study to identify the aetiology and factors associated with outcome
of community-acquired sepsis and severe sepsis in Northeast Thailand.
Potential study participants will be adult patients who are presented at the hospital with
community-acquired sepsis. Clinical specimens (including blood, urine, sputum and throat
swabs) will be collected from each participant on admission for culture, PCR and serological
tests, and other laboratory tests, including inflammatory markers and genotyping.
Participants' treatment will be closely monitored during the duration of their hospital stay.
Blood will be again collected at 72 hours after admission. Participants will be contacted at
28 days after admission to determine clinical outcome by phone interview with standardized
script.
There will be a total of 5,020 patients enrolled in this study over 3 years.
Primary objective: To determine the causes of community-acquired sepsis and severe sepsis in
NE Thailand.
Secondary Objectives:
1. To define the clinical outcome of community-acquired sepsis and severe sepsis in NE
Thailand.
2. To determine factors associated with inflammatory response, organ failure, and mortality
in community-acquired sepsis and severe sepsis in NE Thailand, including causes of
sepsis, sepsis resuscitation, antimicrobial treatment and genetic factors.
3. To evaluate diagnostic tests for infection in community-acquired sepsis and severe
sepsis in NE Thailand.
NOTE: THIS STUDY IS CO-SPONSORED BY
1. University of Oxford
2. University of Washington
;
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