Sepsis Clinical Trial
Official title:
Procalcitonin to Shorten Antibiotics Duration in ICU Patients- A China, Hong-Kong, Taiwan Multicenter Trial
The trial is aimed to show that implementation of a procalcitonin-guided antibiotics algorithm may result in shortened antibiotics course in ICU sepsis patients without inferior outcome as compared to the conventional therapy
The duration of antibiotic therapy in patients with sepsis is largely empirical. An extended
treatment course for up to two weeks is a common practice for patients with sepsis in the
ICU, despite lack of evidence for this duration of therapy.
Procalcitonin (PCT) is a new biomarker that has high negative predictive value for systemic
bacterial infection. The purpose of this trial is to evaluate whether serial PCT
measurements can shorten antibiotic treatment duration in patients with sepsis in the ICU.
Specific Aims
1. To show that implementation of a procalcitonin-guided antibiotics stewardship algorithm
may result in shortened antibiotics course in ICU sepsis patients
2. To show that implementation of a procalcitonin-guided antibiotics stewardship algorithm
may not result in inferior outcome as compared to conventional therapy
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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