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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01135277
Other study ID # 2009H0165
Secondary ID
Status Completed
Phase N/A
First received May 26, 2010
Last updated April 8, 2016
Start date February 2010
Est. completion date November 2012

Study information

Verified date April 2016
Source Ohio State University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. One measure of this sepsis-induced immune suppression is monocyte deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.


Description:

Sepsis is a systemic inflammatory response to a severe infection. Despite the high incidence and societal costs of sepsis, the mechanism by which it kills remains unclear. The pathophysiology of sepsis is not completely understood, but many investigators now believe that sepsis induces a prolonged state of immune suppression. This study will attempt to quantify the degree of immune suppression during the first 5 days of sepsis by measuring the immune function of peripheral blood monocytes and the inflammasome constituent proteins in peripheral blood monocytes and alveolar macrophages.


Recruitment information / eligibility

Status Completed
Enrollment 50
Est. completion date November 2012
Est. primary completion date November 2012
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

1. = 18 years.

2. Have consensus criteria for sepsis (infection plus two of four systemic inflammatory response syndrome [SIRS] signs [tachycardia, tachypnea, fever or hypothermia, leukocytosis or leukopenia]) and a known or suspected infection for SEPTIC arm.

- Patients without criteria for sepsis will be eligible for CONTROL arm. Patient must consent to have blood drawn within 24 hours of initiation of mechanical ventilation (for CONTROL arm) and 24 hours of new episode of sepsis to be eligible (for SEPTIC arm).

Exclusion Criteria:

1. Consent not available or declined

2. Prisoner

3. Died before blood collected

4. Onset of sepsis more than 24 hours prior to transfer to OSUMC,mechanical ventilation greater than 24 hours

5. Anticipation of less than 24 hours of mechanical ventilation by primary team

6. Women who are pregnant.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Locations

Country Name City State
United States The Ohio State University Columbus Ohio

Sponsors (1)

Lead Sponsor Collaborator
Matthew Exline

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. Blood and BAL fluid will be collected at Day 1 Day 1 No
Primary Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. Blood and BAL fluid will be collected at Day 3 Day 3 No
Primary Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. Blood and BAL fluid will be collected at Day 5 Day 5 No
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