Sepsis Clinical Trial
— iVAPOfficial title:
Immune Suppression and Ventilator Associated Pneumonias
Verified date | April 2016 |
Source | Ohio State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. One measure of this sepsis-induced immune suppression is monocyte deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.
Status | Completed |
Enrollment | 50 |
Est. completion date | November 2012 |
Est. primary completion date | November 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. = 18 years. 2. Have consensus criteria for sepsis (infection plus two of four systemic inflammatory response syndrome [SIRS] signs [tachycardia, tachypnea, fever or hypothermia, leukocytosis or leukopenia]) and a known or suspected infection for SEPTIC arm. - Patients without criteria for sepsis will be eligible for CONTROL arm. Patient must consent to have blood drawn within 24 hours of initiation of mechanical ventilation (for CONTROL arm) and 24 hours of new episode of sepsis to be eligible (for SEPTIC arm). Exclusion Criteria: 1. Consent not available or declined 2. Prisoner 3. Died before blood collected 4. Onset of sepsis more than 24 hours prior to transfer to OSUMC,mechanical ventilation greater than 24 hours 5. Anticipation of less than 24 hours of mechanical ventilation by primary team 6. Women who are pregnant. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | The Ohio State University | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Matthew Exline |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. | Blood and BAL fluid will be collected at Day 1 | Day 1 | No |
Primary | Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. | Blood and BAL fluid will be collected at Day 3 | Day 3 | No |
Primary | Immune suppression during the recovery from critical illness is greater in severe sepsis patients compared to non-septic patients. | Blood and BAL fluid will be collected at Day 5 | Day 5 | No |
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