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NCT00889083 Clinical Trial

Hepatic Mitochondrial Function in Sepsis

Sepsis Clinical Trial

Official title:
Evaluation of Hepatic Mitochondrial Function in Sepsis

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT00889083
Other study ID # IAAM-2009-1
Secondary ID
Status Withdrawn
Phase
First received
Last updated
Start date April 2009
Est. completion date April 2012

Study information
Verified date July 2020
Source Institut d'Anesthesiologie des Alpes Maritimes
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date April 2012
Est. primary completion date April 2012
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Septic group : Peritonitis patients needing surgery

- Non septic group : Patients needing hepatic surgery

Exclusion Criteria:

- No liver biopsy performed

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
France CHU de Nice Nice

Sponsors (1)
Lead Sponsor Collaborator
Professor C ICHAI

Country where clinical trial is conducted

France, 

References & Publications (2)

Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002 Jul 20;360(9328):219-23. — View Citation

Fredriksson K, Hammarqvist F, Strigård K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1044-50. Epub 2006 Jun 27. Erratum in: Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1240. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Mitochondrial complex activities during surgery
Secondary Quantification of adenine nucleotides during surgery
Secondary Quantification of oxidative stress markers during surgery
Secondary Correlation between SOFA score and mitochondrial complex activities 28 days
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