Sepsis Clinical Trial
Official title:
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
NCT number | NCT00745888 |
Other study ID # | 9561709132 |
Secondary ID | |
Status | Recruiting |
Phase | Phase 3 |
First received | September 2, 2008 |
Last updated | September 4, 2009 |
Start date | May 2007 |
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute
lung injury, and acute respiratory distress syndrome. There are some questions on the
oxidative stress of the critical illness. First, the investigators want to search out the
effects of the past history, smoking, alcohol drinking, use of antioxidants, different
diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides
total count of ROS, the investigators used new techniques to determine superoxide(O2●-),
hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate
the correlation of the degree of different reactive oxygen species and the severity of SIRS
or shock. Third, we try to investigate the correlation between the change of oxidative
stress and the prognosis of the patients.
The investigators wish this study will help them to investigate the effect of oxidative
stress on critical ill patients, to modulate the oxidative stress, to decrease the
occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of
patients.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Age > 18 y/o - Admitted to surgical ICU Exclusion Criteria: - Patients with brain death |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 28-day Survival | 28 days | No | |
Secondary | Days stay in ICU Days on ventilator SOFA score Complications | 28 days | No |
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