Sepsis Clinical Trial
Official title:
Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis
Patients with alcohol use disorders are often cared for in the intensive care unit (ICU). We
estimate that close to half of the patients we care for in our ICU have alcohol use
disorders. One of the reasons that patients with alcohol use disorders are frequently cared
for in our ICU is because patients with alcohol use disorders are at higher risk of
developing infections. The medical term for infections is sepsis. When an infection
develops, patients with alcohol use disorders tend to get more severely ill compared to
patients who do not have alcohol use disorders. Patients with alcohol use disorders are also
at higher risk of dying when they develop severe infections.
The purpose of this study is to determine why patients with alcohol use disorders become
more severely ill when they develop infections. There are a number of reasons why this is
possible. One reason is that a hormone called cortisol is higher in individuals with alcohol
use disorders (who do not have infections). This hormone is also higher in patients who are
at increased risk of dying from severe infections. One of the aims of this study is to see
if cortisol levels are higher in patients with alcohol use disorders compared to those who
do not have alcohol use disorders.
Another reason why patients with alcohol use disorders are at increased risk of developing
infections is because their immune system is not functioning properly. A second aim of this
study is to see if certain markers of immune function are different in patients with alcohol
use disorders compared to patients without alcohol use disorders.
Patients with alcohol use disorders are also more likely to become confused when they are in
the ICU. This condition is called delirium. Delirium is marked by abrupt onset of altered
level of consciousness, disorganized thinking, and inattention that changes over time.
Delirium tremens is one form of delirium. About 80% of our ICU patients develop delirium,
and many patients who do not have alcohol use disorders develop the disorder as well.
Patients with alcohol use disorders who have high cortisol levels have a higher chance of
developing delirium compared to patients with normal cortisol levels. A third aim of this
study is to examine the relationship between delirium and cortisol in both patients with and
without alcohol use disorders.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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