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NCT00410111 Clinical Trial

Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Sepsis Clinical Trial

Official title:
A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00410111
Other study ID # EKBB 226/06
Secondary ID
Status Completed
Phase N/A
First received December 11, 2006
Last updated October 15, 2008
Start date January 2007
Est. completion date July 2007

Study information
Verified date October 2008
Source University Hospital, Basel, Switzerland
Contact n/a
Is FDA regulated No
Health authority Switzerland: Federal Office of Public Health
Study type Observational

Clinical Trial Summary

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Recruitment information / eligibility
Status Completed
Enrollment 23
Est. completion date July 2007
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 16 Years and older
Eligibility Inclusion Criteria:

- Sepsis

- Admission to ICU

Exclusion Criteria:

- CNS infection

- History of cerebrovascular disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland Operative Intensivbehandlung, University of Basel Hospital Basel

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

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