Sepsis Clinical Trial
Official title:
Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis
The hypothesis of this study is that bioenergetic failure in human sepsis, related to endocrine, metabolic and mitochondrial dysfunction, is a major determinant of defective host immune responses, increasing disease severity and risk of death. The objectives of this study are to examine the relationship between the severity of illness, and temporal changes in the activity of endocrine, metabolic and bioenergetic pathways, and consequent immune dysfunction in critically ill patients with sepsis and multiple organ failure in the Intensive Care Unit.
The objectives of this study are to examine the relationship between the severity of
illness, and temporal changes in the activity of endocrine, metabolic and bioenergetic
pathways, and consequent immune dysfunction in critically ill patients with sepsis and
multiple organ failure in the Intensive Care Unit.
This study will be undertaken using sequential blood sampling (until ICU discharge) and
muscle biopsies (to a maximum of 5) in critically ill patients (a) with or (b) without
sepsis plus a comparator group undergoing elective orthopaedic surgery. A variety of
hormonal, cytokine, immune and mitochondrial measures wil lbe then made to assess whether
any relationship exists between alterations in these different pathways, and whether
eventual survivors and non-survivors can be distinguished.
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Observational Model: Defined Population, Time Perspective: Cross-Sectional
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