Oxygen Toxicity: Mechanisms in Humans

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: - How does the training of respiratory muscles affect oxygen toxicity? - How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? - How does immersion in water affect the development of oxygen toxicity? Participants will be asked to do the following: - Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests - Train their respiratory muscles at regular intervals - Exercise on a cycle ergometer both in dry conditions and underwater/under pressure in the context of medication, sleep deprivation, or carbon dioxide exposure Researchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05761756
Study type	Interventional
Source	Duke University
Contact	Derek B Covington, MD
Phone	919-613-8881
Email	derek.covington@duke.edu
Status	Recruiting
Phase	N/A
Start date	November 28, 2023
Completion date	March 2026

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02850913` - Doxycycline for the Treatment of Nodding Syndrome	Phase 2
Recruiting	`NCT04076449` - Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Not yet recruiting	`NCT06045676` - Electrocardiographic Changes Among Epileptic and Non Epileptic Seizures in Children at Sohag University Hospital
Completed	`NCT03722212` - Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Completed	`NCT02897856` - Efficacy and Safety of Intramuscular Midazolam Compared to Buccal Midazolam in Pediatric Seizures	Phase 4
Completed	`NCT01239212` - Dosing of Levetiracetam (Keppra) in Neonates	Phase 1/Phase 2
Completed	`NCT01236001` - Belgian Drug-utilization Study to Evaluate the Use of VIMPAT® as Adjunctive Treatment of Partial Onset Seizures in Subjects Aged 16 and Older	N/A
Completed	`NCT01702623` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fasted Conditions	Phase 1
Completed	`NCT01703468` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fed Conditions	Phase 1
Recruiting	`NCT02216500` - Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy	N/A
Completed	`NCT00236717` - A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy	Phase 3
Terminated	`NCT03954314` - DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Phase 3
Completed	`NCT05103735` - Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Terminated	`NCT03790436` - Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet	N/A
Completed	`NCT06451289` - Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
Recruiting	`NCT02552511` - Epidemiology Study on Neonatal Seizure
Recruiting	`NCT05339126` - RNS System LGS Feasibility Study	Phase 2
Active, not recruiting	`NCT04595786` - The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection	N/A
Recruiting	`NCT04770337` - Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy	N/A