Observational & Diagnostical Study on Transient Allostatic Responses of

Status Recruiting

Clinical Trial Summary

Changes of thyroid function may occur after short loss of consciousness, but they haven't been systematically evaluated up to now, although occasional observations suggest temporal increases in TSH concentration. This study aims at assessing transient changes of biomarkers of thyroid function after syncopation and seizure. Results of the study might contribute to an improved detection rate of thyrotoxicosis.

Clinical Trial Description

Transient allostatic responses of thyroid function have been described in critical illness. Own observations suggest similar reactive responses after syncopation and cerebral seizures. They are marked especially by increased concentration of serum thyrotropin (TSH), suggesting a type 2 allostatic response. However, changes of thyroid function after temporal loss of consciousness haven't been systematically evaluated up to now. Current diagnostic guidelines recommend primarily the determination of serum TSH concentration for screening of thyroid function, and the measurement of peripheral thyroid hormones (T4 and/or T3) is only recommended if TSH determination results in pathological values. This TSH reflex strategy may be misleading after short-term loss of consciousness. This study aims at assessing the prevalence of allostatic responses of thyroid function after events of syncopation or seizure and at investigating the consecutive temporal development of biomarkers of thyroid function. An additional aim includes the diagnostic value of TSH determination, compared to measurement of free thyroid hormones, for thyroid dysfunction after syncopation or seizure. Results of this study might contribute to an improved detection rate of thyrotoxicosis. In cases of medical emergencies and in-patient treatment interventions with a significant iodine load are common, including the application of iodinated radiocontrast agents and amiodarone. In this setting, undetected hyperthyroidism may lead to thyroid storm, which is associated with a high mortality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04879147
Study type	Observational
Source	Ruhr University of Bochum
Contact	Johannes W Dietrich, M.D.
Phone	+49-234-302
Email	johannes.dietrich@ruhr-uni-bochum.de
Status	Recruiting
Phase
Start date	May 5, 2021
Completion date	May 13, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02850913` - Doxycycline for the Treatment of Nodding Syndrome	Phase 2
Recruiting	`NCT04076449` - Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Not yet recruiting	`NCT06045676` - Electrocardiographic Changes Among Epileptic and Non Epileptic Seizures in Children at Sohag University Hospital
Completed	`NCT03722212` - Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Completed	`NCT02897856` - Efficacy and Safety of Intramuscular Midazolam Compared to Buccal Midazolam in Pediatric Seizures	Phase 4
Completed	`NCT01239212` - Dosing of Levetiracetam (Keppra) in Neonates	Phase 1/Phase 2
Completed	`NCT01236001` - Belgian Drug-utilization Study to Evaluate the Use of VIMPAT® as Adjunctive Treatment of Partial Onset Seizures in Subjects Aged 16 and Older	N/A
Completed	`NCT01702623` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fasted Conditions	Phase 1
Completed	`NCT01703468` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fed Conditions	Phase 1
Recruiting	`NCT02216500` - Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy	N/A
Completed	`NCT00236717` - A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy	Phase 3
Terminated	`NCT03954314` - DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Phase 3
Completed	`NCT05103735` - Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Terminated	`NCT03790436` - Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet	N/A
Completed	`NCT06451289` - Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
Recruiting	`NCT02552511` - Epidemiology Study on Neonatal Seizure
Recruiting	`NCT05339126` - RNS System LGS Feasibility Study	Phase 2
Active, not recruiting	`NCT04595786` - The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection	N/A
Recruiting	`NCT04770337` - Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation and Seizure — Thyro-Syncope

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms