Seizures Clinical Trial
Official title:
Analysis of the Occurrence of Perilesional Edema and Seizures in Patients With Inactive Cysticercosis
Verified date | April 4, 2012 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study will examine what causes seizures in patients with cysticercosis (pork tapeworm
infection). A better understanding of this could lead to improved methods of controlling or
preventing seizures.
In humans, the pork tapeworm (Taenia solium) lives in the small intestine. The parasite's
microscopic eggs travel around the body-including to the brain-where they develop into cysts.
Usually, the cysts don't cause symptoms until they die. Then, they provoke an inflammatory
reaction that irritates the brain, causing seizures and other symptoms. The inflammation
eventually goes away, but the dead cysts remain. Calcium deposits often form where the cysts
are. Some of the calcified cysts develop swelling around them that seem to be associated with
the development of seizures.
This study will explore how and why these dead, calcified cysts continue to cause seizures.
In so doing, it will try to determine: 1) the best diagnostic imaging method for detecting
swelling around the cysts; 2) how often swelling occurs; and 3) what makes some cysts prone
to swelling and related seizure activity, while others are not.
Patients with cysticercosis who have had seizures or who have known or possible swelling
around calcified cysts will be studied with various tests, including magnetic resonance
imaging (MRI), computed tomography (CT) scans, electroencephalography (EEG), blood tests, and
possibly lumbar puncture. Patients will be studied for two cycles of seizures (during active
and quiet periods) or a maximum 4 years.
Status | Completed |
Enrollment | 6 |
Est. completion date | April 4, 2012 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
- INCLUSION CRITERIA: 18 years of age or older. If children are evaluated they can be seen under the general protocol and they may be entered into the present protocol under an exception. Likely diagnosis of inactive cysticercosis and present or past seizure activity. Requires "a" and "b" plus any one of the remaining criteria: 1. History of seizures or present seizure activity; 2. Previously treated or has inactive disease and declines treatment; 3. Single calcified lesions and positive serology; 4. Multiple calcified lesions; 5. Multiple small enhancing nodular lesions; 6. History of cystic lesions responding to specific chemotherapy. If female, not pregnant and using effective birth control methods. EXCLUSION CRITERIA: Less than 18 years of age. Pregnant or unwilling to use effective birth control measures. Refuse blood tests. Unwilling or unable to undergo testing according to the schedule. Unable to undergo MRI or CT examinations. Patients who require anesthesia to undergo imaging studies. |
Country | Name | City | State |
---|---|---|---|
Peru | Universidad Peruana Cayetano Heredia | Lima | |
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Allergy and Infectious Diseases (NIAID) |
United States, Peru,
Nash TE, Neva FA. Recent advances in the diagnosis and treatment of cerebral cysticercosis. N Engl J Med. 1984 Dec 6;311(23):1492-6. Review. — View Citation
Rajshekhar V, Chacko G, Haran RP, Chandy MJ, Chandi SM. Clinicoradiological and pathological correlations in patients with solitary cysticercus granuloma and epilepsy: focus on presence of the parasite and oedema formation. J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):284-6. — View Citation
White AC Jr. Neurocysticercosis: a major cause of neurological disease worldwide. Clin Infect Dis. 1997 Feb;24(2):101-13; quiz 114-5. Review. — View Citation
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