Sedentary Lifestyle Clinical Trial
Official title:
Can Physical Activity During Pregnancy Improve Maternal and Offspring Vascular Health?
Verified date | February 2019 |
Source | Liverpool John Moores University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this study is to determine the effect of aerobic exercise on maternal and offspring vascular health.
Status | Active, not recruiting |
Enrollment | 20 |
Est. completion date | August 3, 2019 |
Est. primary completion date | May 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Healthy pregnant female - No history of cardiovascular disease, gestational diabetes or pre-eclampsia - Single gestation - Not on medication affecting cardiovascular health - A non-smoker for at least 6 months - Participating in structured exercise <twice/week - BMI <30kg/m^2 - Exclusion Criteria: - Royal College of Obstetricians and Gynaecologists (RCOG) contraindications for pregnancy - Pregnant by in-vitro fertilisation (IVF)exercise - BMI >30kg/m^2 - >45 years old - Structured exercise >twice/week - Multiple gestation - Disability preventing ambulation - Currently smoking or smoking within past 6 months prior to pregnancy - Non-English speaking women |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Research Institute for Sport and Exercise Sciences (RISES) | Liverpool | Merseyside |
Lead Sponsor | Collaborator |
---|---|
Liverpool John Moores University | Liverpool Women's NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Offspring Vascular Structure | Offspring vascular structure will be assessed at the abdominal aorta site using ultrasound imaging. Wall thickness will be measured at three different angles of an optimised ultrasound image. The image will be adjusted so that artery wall thickness can be clearly seen and a 30 second recording taken at three different angles. The average of the three angles will be calculated for each artery. Results will be reported as change in millimetres at each time point for each artery assessed. | Assessed within 4 weeks of delivery | |
Other | Change in Cerebrovascular Function | Change in cerebrovascular function will be assessed using transcranial Doppler ultrasound to measure brain blood flow velocity. | Change from baseline at week 24 and 36 of pregnancy | |
Other | Change in Vascular Structure | Vascular structure will be measured at carotid, femoral and brachial arteries using ultrasound imaging to clearly visualise the artery. The image will be adjusted so that artery wall thickness can be clearly seen and a 30 second recording taken at three different angles. The average of the three angles will be calculated for each artery. Results will be reported as change in millimetres at each time point for each artery assessed. | Change from baseline at week 24 and 36 of pregnancy | |
Primary | Change in Vascular Function | Vascular function will be measured via endothelial-dependent flow-mediated dilation (FMD) of the brachial and femoral arteries and reported as percentage change. | Change from baseline at week 24 and 36 of pregnancy | |
Secondary | Change in Sedentary behaviour | Sedentary behaviour will be measured using an inclinometer at the end of each trimester for a period of 7 days in line with the accelerometer monitoring and will be reported in minutes. | Change from baseline at week 24 and 36 of pregnancy | |
Secondary | Change in Physical activity | Physical activity will be monitored for a period of 7 days using accelerometry at the end of each trimester. | Change from baseline at week 24 and 36 of pregnancy | |
Secondary | Incidence of Pregnancy specific outcomes | Following delivery the investigator will obtain information regarding pregnancy specific outcomes including pre-term birth, delivery complications, induction of labour, caesarean section and post-partum haemorrhage via medical notes at the collaborating hospital. | Following delivery and within 4 weeks |
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