Influence of Sedentary Time on Skeletal Muscle Protein Metabolism

Status Completed

Clinical Trial Summary

This study will investigate the influence of increased sedentary time on long-term measures of muscle protein synthesis and metabolic health. The investigators will test the hypothesis that increased time spent in sedentary behaviours will lead to a reduction in long-term measures of muscle protein synthesis and compromised metabolic health.

Clinical Trial Description

Sarcopenia, the loss of muscle mass with age, is thought to be accelerated by an inactive, sedentary lifestyle. Increased sedentary time has consistently been associated with lower muscle mass and compromised metabolic health. However, there is currently a lack of direct evidence to support these associations.

Therefore, this study will investigate whether increased sedentary time (reduced step count and exercise cessation) directly influences long-term measures of muscle protein synthesis and metabolic health in young, active adults. Following a 7 day period of normal habitual physical activity, participants will undertake a 7 day period of step reduction and exercise cessation. It is hypothesised that 7 days of increased sedentary time will result in a reduction in long-term rates of muscle protein synthesis and a worsening of metabolic health. ;

Study Design

Related Conditions & MeSH terms

Sedentary Lifestyle

Clinical Trial Details

NCT number	NCT02624011
Study type	Interventional
Source	University of Birmingham
Contact
Status	Completed
Phase	N/A
Start date	March 2016
Completion date	February 2018

View Details

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