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Clinical Trial Summary

This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.


Clinical Trial Description

This research will include 120 healthy volunteers and 120 brain tumor patients; the participants will be allocated into midazolam, dexmedetomidine and propofol group. Resting and task fMRI will be performed at awake (BIS>90), mild sedation (BIS 80-85), moderate sedation (BIS 65-75), deep sedation (BIS 45-55) and recovery states (BIS >90). The primary outcome of our study is the effect of different levels of sedation for brain network connection. The secondary outcomes are the effect of different levels of sedation for default, executive control, sensory and motor networks and their subnetwork connectivity; the sedation state, circulatory and respiratory parameters of the participants, and the adverse events. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03343873
Study type Interventional
Source Beijing Tiantan Hospital
Contact Ruquan Han, M.D., Ph.D
Phone 8610-67096660
Email ruquan.han@gmail.com
Status Recruiting
Phase N/A
Start date April 1, 2017
Completion date December 31, 2021

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