DNA Vaccine for Ragweed Allergic Adults

Status Completed

Clinical Trial Summary

Various chemical modifications of allergens have been attempted to enhance efficacy, improve safety, and foster compliance with IT. These approaches have been unsuccessful - in that the allergenicity and immunogenicity have either decreased, or increased in tandem, with no resultant efficacy: safety benefit ratio. This study utilizes an adjuvant approach in which synthetic immunostimulatory DNA is conjugated to ragweed allergen in an attempt to modulate both the clinical and immunologic allergic response to ragweed exposure in ragweed-allergic patients with seasonal rhinitis.

Clinical Trial Description

Evaluation of efficacy and safety of allergen-CpG oligonucleotide immunostimulatory conjugate in treatment of ragweed-induced seasonal allergic rhinitis. Study incorporates clinical outcomes (symptom diaries, medication diaries, visual analog scores, quality of life questionnaires), safety measurements, immunologic assays (antibody measurements, T-cell assays, cytokine assays, nasal provocation). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00346086
Study type	Interventional
Source	Johns Hopkins University
Contact
Status	Completed
Phase	Phase 2
Start date	May 18, 2001
Completion date	August 21, 2001

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See also
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