Severity of Scorpion Sting in Relation to Hematological Parameters

Scorpion Stings Clinical Trial

Official title:

Severity of Scorpion Sting in Relation to Hematological Parameters

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04571411
• Other study ID #: scorpion sting in children
• Status: Not yet recruiting
• Start date: December 1, 2020
• Est. completion date: September 1, 2023

Study information

• Verified date: October 2020
• Source: Assiut University
• Contact: Sarah Osama Mohamed, master
• Phone: 01026662002
• Email: saso_monier_2020[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to investigate the relationship between severity of envenomation and hematological parameter by detectig initial mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in pediatric patients presenting with a scorpion sting.

Description:

Scorpion stings are common emergency events in many parts of the world. It is common in tropical and subtropical regions. In our locality, Upper Egypt, scorpions still represent and a life hazard, especially to children .The clinical manifestations of scorpionism are due to complex interactions between sympathetic and parasympathetic stimulation.This leads to increased release of neurotransmitters and mediators, resulting in a cascade of pathological events, involving the nervous system, the cardiovascular and the respiratory system, eventually leading to death.Scorpionism results in hormonal and biochemical changes with significant release of catecholamines, increased angiotensin II and inhibition of insulin secretion .The symptoms and signs of envenomation are usually more severe in children, especially younger ones. Local pain represent 66 to 90 percent of stings which is practically immediate, of varying intensity ranging from mild to very intense. It is characterized by tingling, burning, or stinging. Regardless of the severity of envenoming, pain and paresthesia may persist at the site or at the affected limb for several days .Systemic effects become apparent in 10 to 33 percent of patients.After envenomation, symptoms may begin immediately and typically progress to maximum severity within 5 hours. The clinical effects of stings are characterized, cardiovascular, neurological and gastrointestinal effects .Cardiovascular effects are atrial tachycardia, ventricular extrasystoles, T-wave inversion, ST-T wave changes, bundle-branch block. Catecholamine-induced myocarditis and myocardial ischemia results in pulmonary edema and cardiogenic shock.Cardiovascular effects are atrial tachycardia, ventricular extrasystoles, T-wave inversion, ST-T wave changes, bundle-branch block. Catecholamine-induced myocarditis and myocardial ischemia results in pulmonary edema and cardiogenic shock..Gastrointestinal effects: are vomiting, abdominal pain and diarrhea. Also acute pancreatitis has been reported.Cardiovascular toxic effects and acute pulmonary edema are the most important complications of scorpion stings and the most frequent cause of death in the first 24 hours after the sting .Gastrointestinal effects: are vomiting, abdominal pain and diarrhea. Also acute pancreatitis has been reported.Cardiovascular toxic effects and acute pulmonary edema are the most important complications of scorpion stings and the most frequent cause of death in the first 24 hours after the sting .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: September 1, 2023
• Est. primary completion date: March 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• a) Patients presented with scorpion sting

Exclusion Criteria:

• All other envenomation or intoxications

Related Conditions & MeSH terms

• Bites and Stings
• Scorpion Stings

Intervention

Other:
• CBC
The aim of this study is to investigate the relationship between severity of envenomation and hematological parameter by detectig initial mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in pediatric patients presenting with a scorpion sting.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (8)

Adiguzel S, Ozkan O, Inceoglu B. Epidemiological and clinical characteristics of scorpionism in children in Sanliurfa, Turkey. Toxicon. 2007 May;49(6):875-80. Epub 2007 Jan 10. — View Citation

Ahmed AE, Abdel-Baseer KA, Saad K, Hassan AF, El-Houfey AA. Endocrinological and biochemical changes of scorpionism in children in Upper Egypt. Ther Adv Endocrinol Metab. 2015 Oct;6(5):210-6. doi: 10.1177/2042018815593034. — View Citation

Ait Laaradia M, El Hidan MA, Marhoume F, Bouimeja B, Oufquir S, Sokar Z, Boumezzough A, Chait A. Buthus lienhardi venom and pathophysiological effects at the histological, hematological, biochemical and motor skills levels. Toxicon. 2018 May;146:106-113. — View Citation

Chippaux JP. Estimating the global burden of snakebite can help to improve management. PLoS Med. 2008 Nov 4;5(11):e221. doi: 10.1371/journal.pmed.0050221. — View Citation

Chippaux JP. Management of scorpion stings in Africa and the Mediterranean region. Med Sante Trop. 2016 May 1;26(2):130-3. doi: 10.1684/mst.2016.0571. — View Citation

Cupo P. Clinical update on scorpion envenoming. Rev Soc Bras Med Trop. 2015 Nov-Dec;48(6):642-9. doi: 10.1590/0037-8682-0237-2015. Review. — View Citation

Horoz ÖÖ, Yildizdas D, Aslan N, Gökay SS, Ekinci F, Erdem S, Haytoglu Z, Sertdemir Y, Yilmaz HL. Is there any relationship between initial hematological parameters and severity of scorpion envenomation? Turk J Pediatr. 2020;62(3):394-404. doi: 10.24953/tu — View Citation

Shamoon Z, Peterfy RJ, Hammoud S, Khazaeni B. Scorpion Toxicity. 2020 Sep 15. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK430928/ — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The aim of this study is to investigate the relationship between severity of envenomation and hematological parameter	All patient will be conducted to: full history including: (Age, gender, weight, time and date of presentation; Full examination including : local; General Cardiac examination Chest examination	baseline