Scleroderma Clinical Trial
Official title:
Acoustic Radiation Force Impulse/Shear Wave Velocity Imaging of the Skin in Scleroderma and Other Rheumatologic Diseases
Scleroderma and other rheumatologic conditions can affect the skin. Scleroderma in particular
involves skin thickening and hardening.
Currently, looking at the degree that the skin is affected by scleroderma is measured based
on a combination of a physical exam and a skin biopsy.
The researchers propose to measure skin hardness using ultrasound imaging of elasticity. They
will use a technique using acoustic radiation force impulse/shear wave velocity imaging ,
known as ARFI/SVI).
The investigators hypothesize that ARFI/SVI may be able to distinguish between normal skin
and skin affected by scleroderma.. This tool may also help to quantify the amount of fibrosis
in the skin.
This type of radiologic biomarker could be used to help confirm the diagnosis of scleroderma.
Scleroderma as well as numerous other rheumatologic conditions can affect the skin.
Scleroderma in particular causes skin thickening and hardening.
Currently, evaluation of degree to which skin is affected by scleroderma is measured by a
combination of a physical exam and skin biopsy results.
The investigators propose to measure skin hardness using ultrasound elasticity imaging, in
the form of acoustic radiation force impulse/shear wave velocity imaging (ARFI/SVI).
The investigators hypothesize that ARFI/SVI may be able to distinguish normal skin from skin
affected by scleroderma (and other rheumatologic conditions). And, this ultrasound technique
might measure the amount of fibrosis in the dermis (skin).
Such a radiologic biomarker could be used to help confirm the diagnosis of scleroderma. In
addition, it may be usable for following patients over time and measuring their response to
therapy and progression of disease.
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