Clinical Trials Logo
  1. Home
  2. Sciatica
  3. NCT05626140

COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA — EDCLAS  

Sciatica Clinical Trial

Official title:
COMPARISON OF EFFICACY OF DICLOFENAC VERSUS DICLOFENAC PLUS CODEINE AND DICLOFENAC PLUS LACOSAMIDE IN ACUTE SCIATICA

Clinical Trial Summary

The goal of this clinical trial is to compare different combinations of diclofenac with diclofenac monotherapy in acute sciatica. The main questions it aims to answer are: - Does the combination of diclofenac plus codeine better than diclofenac monotherapy for treating severe pain of sciatica - Does the combination of diclofenac plus lacosamide better than diclofenac monotherapy for treating severe pain of sciatica Participants will be asked to mark their pain intensity on a visual analog scale and fill oswestry disabilit index questionnaire,treatments they'll be given includes either 1. Diclofenac monotherapy 2. Diclofenac plus codeine 3. Diclofenac plus lacosamide Researchers will compare the above three groups to see if severity of pain and disability lowered after medication

Clinical Trial Description

Musculoskeletal conditions are the most common cause of intense long-term pain, physical disability and early deaths. They affect hundreds of millions of people of all ages irrespective of social strata globally. Lumbar radicular pain (LRP), commonly referred to as "Sciatica" is a relatively common musculoskeletal disorder. Objective of the study is to evaluate the efficacy of different drug combinations with diclofenac for the treatment of acute sciatica. The design of the study is Single-center, clinical trial with three arms. (Single Blinding). One hundred and twenty patients were enrolled in this study between September 2021 and July 2022 at the Pharmacology department of Islamic International Medical College (IIMC) Rawalpindi in collaboration with the Neurosurgery Department, of Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU) Pakistan Institute of Medical Sciences (PIMS) Islamabad. Informed verbal and written consent was taken from all patients. 40 patients were in the diclofenac (50 mg) plus placebo group, 40 in the codeine (30 mg) plus diclofenac (50 mg) group and 40 in lacosamide (50 mg) plus diclofenac (50 mg) group. Patients were followed up at day 5, 10 and 15 to assess change in pain intensity and functional disability. The use of rescue analgesia was also assessed at the final day of outcome ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05626140
Study type Interventional
Source Pakistan Institute of Medical Sciences
Contact
Status Completed
Phase Phase 3
Start date September 28, 2021
Completion date July 31, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT02384928 - Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation N/A
Withdrawn NCT02313350 - Intradiscal Discogel® in Resistant Sciatica N/A
Unknown status NCT02512081 - "The Lived Experience of Investigations for Sciatica" N/A
Recruiting NCT06179901 - The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents N/A
Terminated NCT02951377 - Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy Phase 1
Completed NCT03347929 - NSAIDs in Sciatica NSAIDS IN SCIATICA Phase 4
Completed NCT04145310 - BOL-DP-o-04 in Patients With Low Back Pain and Sciatica Phase 1/Phase 2
Enrolling by invitation NCT04660656 - Predictive Value of the Five-repetition Sit-to-stand Test After Lumbar Spine surgerySTS-3 Study.
Completed NCT02644421 - Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) Phase 1
Completed NCT00991172 - A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain Phase 2
Completed NCT00668434 - Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica Phase 2
Completed NCT00749996 - Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease Phase 4
Completed NCT00246948 - The Efficacy of Active Conservative Treatment for Patients With Severe Sciatica. A Randomized Clinical Controlled Trial N/A
Completed NCT04155450 - Effects of Extension Biased External Limb Loading in Addition to McKenzie Extension Protocol in Lumbar Derangement Syndrome N/A
Completed NCT02284542 - NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
Recruiting NCT02770963 - Efficacy of Acupuncture for Discogenic Sciatica N/A
Completed NCT00364572 - Efficacy of Epidural Etanercept in the Treatment of Sciatica Phase 1/Phase 2
Completed NCT00470509 - Adalimumab in Severe and Acute Sciatica Phase 2
Active, not recruiting NCT03887962 - Virtual Environment Rehabilitation for Patients With Motor Neglect Trial N/A
Completed NCT05959317 - Effects of Pilates Exercises and Neural Dynamic Mobilization in Sciatica Patients N/A