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Adalimumab in Severe and Acute Sciatica — ASAS  

Sciatica Clinical Trial

Official title:
Adalimumab in Severe and Acute Sciatica

Clinical Trial Summary

The purpose of this study is to determine whether adalimumab (a TNF-alpha inhibitor) is effective in the treatment of severe and acute sciatica.

Clinical Trial Description

Sciatica and low back pain are common problems that lead to major costs in Western countries. The presence of herniated disc is generally considered as the leading cause of sciatica. However, recent findings indicate that the presence of this mechanism is not sufficient to explain all the clinical signs of radiculopathy and that inflammatory mechanisms contribute also to the pathophysiology of sciatica. Indeed, herniated discs contain large amounts of tumor necrosis factor (TNF-alpha) which can induce acute and chronic inflammation and pain. It has recently been demonstrated that TNF-alpha inhibitors (infliximab or etanercept) were able to prevent the occurrence of pain in an experimental model of sciatica. In addition, two independent preliminary studies have shown that patients treated with TNF-alpha inhibitors had better evolution than an historical control group. This study has been designed to verify the hypothesis that TNF-alpha has a major role in human sciatica and that anti-TNF-alpha agents are interesting therapeutic approaches in severe sciatica. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00470509
Study type Interventional
Source University Hospital, Geneva
Contact
Status Completed
Phase Phase 2
Start date May 2005
Completion date June 2008
View Details
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