Clinical Trials Logo

Clinical Trial Summary

There is considerable variation in scarring, within and between people, and between different ethnic groups. Individuals with more pigmented skin are more prone to severe scarring than those traditionally termed white. Prevascar is being developed by Renovo for use as a potential treatment for reducing scarring.

Renovo's histological analysis of wounds and scars in human non drug studies demonstrates an increase in wound and scar width in subjects of African Caribbean ancestry over a 12 month period.

It is hypothesised that IL-10 may be a potentially beneficial therapy for the reduction of scarring in Non Caucasians of African-Caribbean ancestry.

This Renovo clinical trial will be carried out primarily to establish the effects of four doses of Prevascar on 1cm incisional and excisional scars in subjects of African Continental Group ancestry, as compared to placebo, and to further investigate the safety and tolerance of intradermally injected Prevascar in wounds.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01115868
Study type Interventional
Source Renovo
Contact
Status Active, not recruiting
Phase Phase 1
Start date April 2010
Completion date August 2012

See also
  Status Clinical Trial Phase
Withdrawn NCT01995604 - Dehydrated Human Amnion/Chorion Membrane (dHACM) for Recovery After Fractionated Ablative CO2 Laser Resurfacing of the Face N/A
Completed NCT05449457 - Aesthetic Outcome of Layered Closure vs. Layered Closure Followed by 2-Octyl Cyanoacrylate N/A
Withdrawn NCT01704924 - Prospective Observation of Wound Healing With Prevena Incision Management System N/A
Recruiting NCT05758168 - Aesthetic Outcome of Tie-over Bolster Application in Surgical Wounds N/A
Completed NCT03424304 - Evaluation of Cutera Excel V™ Laser With Green Genesis and Micro-Lens Array (MLA)Attachment N/A
Completed NCT02300909 - dHACM in Lumbar Decompression and Microdiscectomy Surgery N/A
Active, not recruiting NCT04383912 - Onabotulinum Toxin A in Direct Brow Lift N/A
Not yet recruiting NCT04593706 - Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars) N/A
Enrolling by invitation NCT06448481 - Aesthetic Outcome of Intra-dermal Versus Transcutaneous Purse-string Closure N/A
Not yet recruiting NCT05470322 - Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients N/A
Recruiting NCT06122090 - Treatment of Hypopigmented Scars With Bimatoprost Phase 2
Completed NCT04331080 - A Study of Granexin® Gel for the Reduction of Scar Formation in Surgical Wounds Following Bilateral Anchor Incision Breast Surgery Phase 2/Phase 3
Completed NCT03036306 - Dose Ranging Study to Evaluate the Safety and Tolerability of SCX-001 Cream in Healthy Volunteers With Induced Dermal Incisions Phase 1
Completed NCT02630303 - High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Phase 1
Completed NCT02088567 - Amniotic Membrane in Total Knee Replacements to Reduce Scarring N/A
Completed NCT03514615 - A Trial to Assess the Safety and Efficacy of Topical Salbutamol in Healthy Volunteers. Phase 1
Completed NCT02676115 - Medipore Tape Study N/A
Completed NCT03424148 - Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attachment N/A
Not yet recruiting NCT04214236 - CiNPT for Abdominoplasties in Post-bariatric Patients Study N/A
Completed NCT02247193 - Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Phase 1/Phase 2