SARS Virus Clinical Trial
Official title:
Immune Cells and the Coronavirus for Inflammatory Arthritis
| Verified date | May 2024 |
| Source | University of Manchester |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
A team at the University of Manchester are developing a test that tcould be helpful in detecting immunity to the Coronavirus (which causes the COVID-19 disease) in participants with inflammatory arthritis. It is based on a flu assay has already developed; the team will replace the flu antigen with a Coronavirus antigen to see if it is effective. This project aims to develop a test to see if people who have had the virus have developed immunity to it. This could help to predict who might or might not get the disease a second time, who should stay at home to be protected from potential infection or who will not develop any symptoms, even if exposed to the virus. When vaccination trials against the Coronavirus will be launched, this test could also help to see if the vaccine is effective.
| Status | Enrolling by invitation |
| Enrollment | 125 |
| Est. completion date | July 31, 2026 |
| Est. primary completion date | July 31, 2026 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Has previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study - Has agreed to be contacted abut future research projects - Has previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study - Is willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample - Has a good written understanding of English Exclusion Criteria: - Has not previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study - Has not agreed to be contacted abut future research projects - Has not previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study - Is not willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample - Has not got a good written understanding of English |
| Country | Name | City | State |
|---|---|---|---|
| United Kingdom | University of Manchester | Manchester | Greater Manchester |
| Lead Sponsor | Collaborator |
|---|---|
| University of Manchester |
United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Prevalence and abundance of CD4+ T lymphocytes | the prevalence and abundance of CD4+ T lymphocytes specifically recognizing SARS-CoV-2 in COVID-19 patients with inflammatory arthritis, in pre- and post-infection samples; in patients without COVID-19 and in healthy volunteers with or without COVID-19. Correlation of these cells with COVID-19 severity. | 2 years |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04527614 -
Influence of Prior Infection With COVID-19 on Occurrence of Influenza-like Illness or Acute Respiratory Infection
|
N/A | |
| Completed |
NCT04453384 -
Study to Evaluate the Safety and Efficacy of XAV-19 in Patients With COVID-19 Induced Moderate Pneumonia
|
Phase 2 | |
| Not yet recruiting |
NCT04357613 -
IMATINIB IN COVID-19 DISEASE IN AGED PATIENTS.
|
Phase 2 | |
| Completed |
NCT04383535 -
Convalescent Plasma and Placebo for the Treatment of COVID-19 Severe Pneumonia
|
N/A | |
| Completed |
NCT04567927 -
Prevalence and Risk Factors for Venous Thromboembolic Events in Critically Ill Patients With COVID-19
|
||
| Recruiting |
NCT04381819 -
Norwegian SARS-CoV-2 Study - Virological, Clinical and Immunological Characterisation of COVID-19
|
||
| Recruiting |
NCT03443102 -
Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome
|
N/A | |
| Completed |
NCT00066209 -
Investigating Severe Acute Respiratory Syndrome (SARS)
|
N/A |