Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

Sars-CoV-2 Infection Clinical Trial

Official title:

Physiological Response to Prone Position in Intubated Adults With COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05092737
• Other study ID #: Prone_COVID
• Status: Completed
• Start date: August 1, 2021
• Est. completion date: April 30, 2022

Study information

• Verified date: October 2021
• Source: University of Lausanne Hospitals
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: April 30, 2022
• Est. primary completion date: April 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• COVID-19 associated moderate to severe ARDS

• Invasive mechanical ventilation

• Prone positioning

• admitted to ICU

Exclusion Criteria:

• already sustained prone positioning in referring hospital

• pronation during ECMO only

• denied consent for data analysis

Related Conditions & MeSH terms

• Acute Lung Injury
• ARDS
• COVID-19
• Respiratory Distress Syndrome
• Respiratory Distress Syndrome, Newborn
• Sars-CoV-2 Infection

Intervention

Procedure:
• Prone positioning
Prone position during invasive mechanical ventilation

Locations

Country	Name	City	State
Switzerland	Lausanne University Hospitals	Lausanne	Vaud

Sponsors (1)

Lead Sponsor	Collaborator
University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PaO2/FiO2	Arterial partial pressure of oxygen / Fraction of inspired oxygen	Within 2 hours before pronation and 2 hours before supination
Secondary	Alveolo-arterial oxygen gradient change		Within 2 hours before pronation and 2 hours before supination
Secondary	Ventilatory Ratio		Within 2 hours before pronation and 2 hours before supination
Secondary	Mortality or Extracorporeal membrane oxygenation (ECMO) support		Once between ICU admission and extubation