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NCT05092737 Clinical Trial

Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

Sars-CoV-2 Infection Clinical Trial

Official title:
Physiological Response to Prone Position in Intubated Adults With COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05092737
Other study ID # Prone_COVID
Secondary ID
Status Completed
Phase
First received
Last updated
Start date August 1, 2021
Est. completion date April 30, 2022

Study information
Verified date October 2021
Source University of Lausanne Hospitals
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Recruitment information / eligibility
Status Completed
Enrollment 31
Est. completion date April 30, 2022
Est. primary completion date April 30, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - COVID-19 associated moderate to severe ARDS - Invasive mechanical ventilation - Prone positioning - admitted to ICU Exclusion Criteria: - already sustained prone positioning in referring hospital - pronation during ECMO only - denied consent for data analysis

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Prone positioning
Prone position during invasive mechanical ventilation

Locations
Country Name City State
Switzerland Lausanne University Hospitals Lausanne Vaud

Sponsors (1)
Lead Sponsor Collaborator
University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary PaO2/FiO2 Arterial partial pressure of oxygen / Fraction of inspired oxygen Within 2 hours before pronation and 2 hours before supination
Secondary Alveolo-arterial oxygen gradient change Within 2 hours before pronation and 2 hours before supination
Secondary Ventilatory Ratio Within 2 hours before pronation and 2 hours before supination
Secondary Mortality or Extracorporeal membrane oxygenation (ECMO) support Once between ICU admission and extubation
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